Yazar "Aksan Kurnaz, Işıl" için listeleme
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ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target
Demir, Özlem; Aysit, Neşe; Önder, Zeynep; Türkel, Nezaket; Öztürk, Gürkan; Sharrocks, Andrew D.; Aksan Kurnaz, Işıl (Elsevier, 2011)Elk-1 belongs to the ternary complex factors (TCFs) subfamily of the ETS domain proteins, and plays a critical role in the expression of immediate-early genes (IEGs) upon mitogen stimulation and activation of the ... -
Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation
Kandemir, Başak; Davis, Sabrina; Yiğit, Esra Nur; Öztürk, Gürkan; Yılmaz, Bayram; Laroche, Serge; Aksan Kurnaz, Işıl (Elsevier Ireland Ltd, 2020)Pea3 proteins belong to a subfamily of the E-twentysix (ETS) domain superfamily of transcription factors, which play various roles during development. Polyoma Enhancer-Activator 3 (Pea3) proteins Pea3, ERM and Er81 are ... -
Multiple sclerosis biomarker candidates revealed by cell-type-specific interactome analysis
Yurduseven, Kübra; Babal, Yigit Koray; Çelik, Eşref; Kerman, Bilal Ersen; Aksan Kurnaz, Işıl (Mary Ann Liebert, 2022)Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as the brain, spinal cord, and optic nerves. Susceptibility to MS, as well as disease progression rates, ... -
Pea3 transcription factor promotes neurite outgrowth
Kandemir, Başak; Çağlayan, Berrak; Hausott, Barbara; Erdoğan, Burcu; Dağ, Uğur; Demir, Özlem; Savaşan Soğut, Melis; Klimaschewski, Lars; Aksan Kurnaz, Işıl (Frontiers Research Foundation, 2014)Pea3 subfamily of E-twenty six transcription factors consist of three major -exhibit branching morphogenesis, the function of Pea3 family in nervous system development and regeneration is only beginning to unfold. In this ... -
A transcriptome based approach to predict candidate drug targets and drugs for Parkinson's disease using an in vitro 6-OHDA model
Yiğit, Esra Nur; Sönmez, Ekin; Yüksel, İsa; Aksan Kurnaz, Işıl; Çakır, Tunahan (Royal Society of Chemistry, 2023)The most common treatment strategies for Parkinson's disease (PD) aim to slow down the neurodegeneration process or control the symptoms. In this study, using an in vitro PD model we carried out a transcriptome-based drug ...